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What Are Psychedelic Drugs Hallucinogenics? Their use predates the written word, with archaeologists confirming their use in ancient ritual and ceremonial contexts. While the ingestion of psychedelics for recreational and sacred purposes has been ongoing, their therapeutic potential was first recognized by scientists in the mid-20th century. Welcome to Leafly’s guide to psychedelics, where we explore the therapeutic and recreational benefits of these amazing substances. That is, although the canonical signaling pathway for the 5-HT2A receptor is Gαq coupling and activation of PLC, it is now known that other signaling pathways can be activated. The relative activation of these different pathways is ligand dependent, has most often been referred to as “functional selectivity” (Urban et al., 2007), and has recently been reviewed (see Seifert, 2013; Zhou and Bohn, 2014). Psilocybin, when administered in a controlled setting, has frequently been reported to cause transient, delayed heada